Induction of apoptosis and inhibition of proliferation of nonmutated BCR-ABL–expressing cells by nilotinib and imatinib. (A) Effects of nilotinib and imatinib, alone and combined, on induction of apoptosis of nonmutated BCR-ABL–expressing cells following 2 days of treatment. (B) Corresponding effects of nilotinib and imatinib, alone and combined, on proliferation of nonmutated BCR-ABL–expressing cells following 2 days of treatment (n = 2 for 32D.p210; n = 1 for KU812). Error bars indicate SEM.