Figure 4
Figure 4. Induction of apoptosis and inhibition of proliferation of imatinib-resistant BCR-ABL–expressing cells by nilotinib and imatinib. (A) Effects of nilotinib and imatinib, alone and combined, on proliferation (left panel; n = 2) and induction of apoptosis (middle and right panels; n = 1) of imatinib-resistant BCR-ABL–expressing cells: F317L. (B) Effects of nilotinib and imatinib, alone and combined, on proliferation (left panel; n = 1) and induction of apoptosis (middle and right panels; n = 1) of imatinib-resistant BCR-ABL–expressing cells: M351T. (C) Effects of nilotinib and imatinib, alone and combined, on proliferation (left panel; n = 2) and induction of apoptosis (middle and right panels; n = 1) of imatinib-resistant BCR-ABL–expressing cells: F486S. (D) Effects of nilotinib and imatinib, alone and combined, on induction of apoptosis of imatinib-resistant BCR-ABL–expressing cells: E255V (n = 1). Where shown, error bars indicate SEM.

Induction of apoptosis and inhibition of proliferation of imatinib-resistant BCR-ABL–expressing cells by nilotinib and imatinib. (A) Effects of nilotinib and imatinib, alone and combined, on proliferation (left panel; n = 2) and induction of apoptosis (middle and right panels; n = 1) of imatinib-resistant BCR-ABL–expressing cells: F317L. (B) Effects of nilotinib and imatinib, alone and combined, on proliferation (left panel; n = 1) and induction of apoptosis (middle and right panels; n = 1) of imatinib-resistant BCR-ABL–expressing cells: M351T. (C) Effects of nilotinib and imatinib, alone and combined, on proliferation (left panel; n = 2) and induction of apoptosis (middle and right panels; n = 1) of imatinib-resistant BCR-ABL–expressing cells: F486S. (D) Effects of nilotinib and imatinib, alone and combined, on induction of apoptosis of imatinib-resistant BCR-ABL–expressing cells: E255V (n = 1). Where shown, error bars indicate SEM.

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