Schematic presentation of the location of RUNX1 mutations. The horizontal bars represent the full linear polypeptide sequence from amino acid 1 to 455 of RUNX1β. Amino acid numbering is given above the bars. The DNA-binding RHD (amino acids 50-177) and the TA domain (amino acids 291-371) are indicated in gray. The location of mutations is indicated by thin vertical lines with the type of mutation on the protein level given in text boxes for (A) the AML M0 cohort and for (B) the non-AML M0 cases.