Defect in p40 production in mast cells leads to decreased survival following CLP. Survival rates of WBB6 F₁^+/+ mice (10 mice/group; ▵), W/W^v mice (10 mice/group; ◇), and W/W^v mice reconstituted with wild-type BMMCs (8 mice/group; ■) or p40^−/− BMMCs (9 mice/group; ●) following CLP induction are shown. Statistical analysis was performed using the log rank test. *P < .05, significantly different from the WBB6 F₁^+/+ mice group. These results are representative of 3 independent experiments that had similar results.