Correlation of mutations in ELA2, encoding NE, with cyclic neutropenia or SCN. There are 2 categories of mutations: those reported exclusively in SCN (blue, below the gene structure) or those reported predominantly in cyclic neutropenia (but that also may have been described in SCN; pink, above the line). *, amino acid substitutions; ▾, deletions (or nonsense mutations); ▴, an insertion. Exon 4 deletions are in frame, and the cluster of exon 5 deletions are all frame-shift, chain-terminating events.