Long-term survival benefit of TF cytoplasmic domain–deleted mice in severe endotoxemia. (A) Kaplan-Meier survival plot of TF^ΔCT (n = 45) versus wild-type (n = 48) male mice after intraperitoneal LPS challenge (6 repeat experiments with 7-8 mice/group). TAT levels (B) as well as IL6, IL1β, and MCP1 inflammatory cytokine levels (C) were measured in separate experiments at 4, 6, 12, and 18 hours in wild-type (filled squares) and TF^ΔCT (open squares) male mice after LPS challenge (TF^ΔCT 4 hours: n = 9; WT 4 hour: n = 8; TF^ΔCT 6 hours: n = 6; WT 6 hours: n = 6; TF^ΔCT 12 hours: n = 6; WT 12 hours: n = 6; TF^ΔCT 18 hours: n = 14; WT 18 hours: n = 14). *denotes significant difference between groups, P < .05 by Mann-Whitney test.