Organ distress in low-PC mice after LPS administration. Plasma levels of CK (A) and LDH (B) at various times after LPS (2 μg/g) in WT (▪) and PC^−/−(PC^Tg785) (□) mice. Heart rate measurements (C) in individual WT (solid lines) and PC^−/−(PC^Tg785) (dashed lines) mice after LPS (2 μg/g, administered at the time marked by the arrow). Plasma levels of ALT (D) and BUN (E) at various times after LPS (2 μg/g) in WT (▪) and PC^−/−(PC^Tg785) (□) mice. For panels A-B and D-E, the data represent the means of n = 3-5 mice from each group. *Statistical significance with P < .05. TUNEL assays showing apoptosis (brown staining) in various organs from WT (F,H,J) and low-PC (G,I,K) mice at 12 hours after LPS (2 μg/g) exposure. Kidney (F-G), liver (H-I), and lung (J-K). Original magnification, × 200 for all panels. (A-B, D-E) Data are represented as mean ± SEM (n = 5).