Inflammatory state in low-PC mice after LPS challenge. CD45⁺ immunostains (brown) in various organs from WT (A-C,G-I) or PC^−/−(PC^Tg785) (D-F,J-L) mice at resting (A-F) and at 6 hours (G-L) after LPS (2 μg/g) administration. Neutrophils in the livers and lungs of WT (M-O) and PC^−/−(PC^Tg785) (N-P) mice, respectively at 6 hours after LPS (2 μg/g) challenge. Original magnification, × 200 for all panels, unless indicated otherwise. Circulating levels of TNF-α (Q) and IL-6 (R) in WT (▪) and low-PC mice (□) at various times after LPS challenge. The values are means of 5 to 12 mice ± SEM.