Course of platelet count and D-dimer among the 15 patients of the evaluation cohort. (A) Platelet count; mean values plus or minus 1 SD. ● represent patients with normal renal function (CrCl > 60 mL/min; n = 5); ○, those with moderately impaired renal function (CrCl 30-60 mL/min; n = 5); ▼, those with severely impaired renal function (CrCl < 30 mL/min; n = 5). (B) Box plot of D-dimers in all 15 patients depicting the median value (horizontal line within the box), the 25th and 75th percentiles (bottom and top borders of the box), the 10th and 90th percentiles (bottom and top whiskers), and outliers outside the 10th and 90th percentiles (●). Day 0 indicates the day of clinical and laboratory evaluation for suspected HIT and start of lepirudin treatment.