Consensus clustering. (A) For each pair of samples in the unsupervised hierarchical cluster analysis, the R measure (the proportion of the time sample pairs stay in the same cluster during consensus clustering) is indicated for each original cluster as an average over all pairs of samples. The R measures for individual pairs of samples are color-coded with white indicating that a given sample pair clustered 100 times in the same group and red denoting no coclustering. The white diagonal line displays the intraindividual comparison of results for a patient with AML (ie, 100× coclustering). (B) Kaplan-Meier estimates of overall survival in the 2 CBF consensus clusters; the difference between cluster no. 1 and no. 2 was significant (P = .046, log-rank test).