Progression of proteinuria in New Zealand black × New Zealand white mice after transplantation. New Zealand black × New Zealand white mice received lethal irradiation followed by allogeneic hematopoietic stem cells, syngeneic hematopoietic stem cells, or syngeneic whole bone marrow transplants. Urine was analyzed monthly for proteinuria (urine protein 1 g/L [100 mg/dL] or over). Three time points after transplantation are shown to illustrate the advancement of proteinuria in some mice. The relative degree of proteinuria is shown, negative less than 1 g/L (100 mg/dL), mild proteinuria 1 g/L (100 mg/dL), severe proteinuria 5 g/L (500 mg/dL). Over 80% of the mice that received allogeneic hematopoietic stem cells (red) did not develop proteinuria. All the untreated age-matched control mice (gray) developed proteinuria. Most mice that received syngeneic whole bone marrow (green) or syngeneic hematopoietic stem cells (blue) developed elevated urine protein. The frequency of proteinuria development in mice that received allogeneic transplants was significantly less than all other groups (P ≤ .001).