Change in dermal fibrosis grade and mRSS after HDIT and autologous HCT. The change in dermal fibrosis grade and mRSS was evaluated in patients from whom we had skin biopsies from both before and after HDIT and autologous HCT (n = 10). The mean decrease in skin score from baseline after HDIT was 19.7 (P < .001; left horizontal line) and was very comparable to the result for the overall group. The mean decrease in the dermal fibrosis grade from baseline was 3.1 (P = .001; right horizontal line) from a mean baseline grade of 4.3. Seven of the 10 patients had a dermal fibrosis grade of 0 to 1 at the time of last skin biopsy. The median follow-up was 4 (range, 1 to 6) years after HDIT and autologous HCT.