Effect of Ang-II on TNFα release and leukocyte accumulation into the rat peripheral cavity. Time course of Ang-II-induced TNFα release (A), neutrophil polymorphonuclear leukocytes [PMNs] (B), and mononuclear leukocyte accumulation (C). Rats were intraperitoneally injected with 5 mL PBS or 1 nM Ang-II. Results are mean (± SEM) for 5 animals per group: *P < .05 or **P < .01 relative to values in the PBS-injected group.