Kaplan-Meier curves for time to first treatment and overall survival for the patient cohort defined by median expression of Bcl-2 family proteins. All of the Bcl-2 family proteins were prognostic for time to first treatment (A,C,E,G,I), and Bcl-2 (B), Bax (D), Mcl-1 (F), Bcl-2/Bax ratios (H), and Mcl-1/Bax ratios (J) were prognostic for overall survival. The hazard ratios, confidence intervals, and P values for each parameter are shown in Table 2.