Kaplan-Meier curves for time to first treatment and overall survival defined by the combination of Mcl-1/Bax ratios and V_H gene mutation status, CD38 expression, and ZAP-70 expression (stage A patient cohort only; n = 129). Mcl-1/Bax ratios in combination with V_H gene mutation status (A,B), CD38 expression (C,D), and ZAP-70 expression (E,F) increased the prognostic power of each parameter in defining time to first treatment. However, in terms of overall survival, the addition of Mcl-1/Bax ratios only improved the prognostic power of ZAP-70 expression.