Schematic of hematopoietic development indicating intermediates in the hierarchy of hematopoietic differentiation. Surface markers used for isolation are indicated at left for human (top) and mouse (bottom) for each stem and progenitor cell. HSC indicates long-term reconstituting, self-renewing; MPP, multipotent progenitors with limited self-renewal leading to transient but multilineage reconstitution; CMP, common myeloid progenitor; CLP, common lymphoid progenitor; BLP, B lymphocyte protenitor; ProT, T-cell progenitor; GMP, granulocyte/macrophage progenitor; MEP, megakaryocyte/erythroid progenitor; MkP, megakaryocyte progenitor; EP, erythroid progenitor. Adapted from Figure 1 in Bryder D, Rossi DJ, Weissman IL. Hematopoietic stem cells: The paradigmatic tissue specific stem cell. Am J Pathol. 2006;169:338-346, with permission from the American Society for Investigative Pathology.