CD4 antitumor effect is generalizable. (A) Rachel, another anti-H-Y CD4 TCR Tg mouse, also rejects MB49. Percentage of RAG.KO mice alive after being challenged with MB49 tumor cells and receiving, 1 day later, either nothing (broken lines), 10⁶ Marilyn cells (triangles), or 10⁶ Rachel cells (an anti-H-Y CD4 transgenic mouse with a different TCR from that of Marilyn). Data from 3 pooled experiments. (B and C) Marilyn's superiority to MataHari is seen with other tumors: percentage of RAG.KO (broken line), MataHari (circles), or Marilyn (triangles) mice that survived challenge with either (B) H-2^b carcinomas: 3 × 10⁵ of WR21 (left panel, a salivary gland carcinoma), 3 × 10⁶ of TRAMP-C2 (right panel, prostate carcinoma), or (C) H-2^k endotheliomas: IP2-E4 (left panel), 3B-11 (middle panel), or H-Y–negative 2F-2B (right panel), 2 × 10⁵ of each.