Probability of achieving MMR in those patients who had not achieved an MMR at 12 months. Patients were divided into 3 groups according to the dose they received in the second year. The first cohort on “suboptimal dose” had already had their dose modified and were on a maximal tolerated dose, which was less than 600 mg/day. The second group were unable to dose escalate but maintained 600 mg/day. The third group were able to increase to 800 mg/day.