Aberrant NF-κB activity induces IL-6 and/or IL-10 production in a subset of DLBCL, which then activates the JAK/STAT pathway in an autocrine manner. The resulting synergistic NF-κB and STAT crosstalk affects lymphoma-cell survival, proliferation, and metabolism.

Aberrant NF-κB activity induces IL-6 and/or IL-10 production in a subset of DLBCL, which then activates the JAK/STAT pathway in an autocrine manner. The resulting synergistic NF-κB and STAT crosstalk affects lymphoma-cell survival, proliferation, and metabolism.

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