15d-PGJ2 enhances platelet number in vivo and accelerates recovery of platelets after ionizing radiation. (A) C57BL/6 mice were injected intravenously with 1 mg/kg 15d-PGJ2 for 4 consecutive days. Platelet number was measured on days 4, 10, and 15. There is a significant increase in the levels of circulating platelets on day 4 in mice treated with 15d-PGJ2. Results are presented as mean plus or minus SD (P < .01; n = 4). (B) C57BL/6 mice were exposed to 5 Gy of total body ionizing irradiation on day 0 and on the following 4 consecutive days, were injected intravenously with 1 mg/kg 15d-PGJ2. Platelet number was measured on days 10, 22, and 31. There is a significant increase in the levels of circulating platelets on days 22 and 31 in mice treated with 15d-PGJ2. Results are presented as means plus or minus SD (P < .01; n = 8).
