Overview of somatic copy number changes in 20 childhood ALL patients. (A) Comparison of copy number changes (relative to germ line) in the matched diagnosis and relapse samples. For each sample (column), copy number changes are indicated by color (blue indicates loss; red, gain) from chromosome 1 to X. Each row represents a segment of the genome. Sample type is indicated by the color bars at the top of each column (orange indicates diagnosis; green, relapse), and numbers denote patient ID. (B) Frequency (number of the affected cases) of somatic copy number gains (red, left panel) and copy number losses (blue, right panel). CNAs in the diagnosis samples are indicated above the baseline (dark red and dark blue), whereas CNAs in the relapse samples are below the baseline (bright red and bright blue). CNAs are mapped according to their chromosomal position, from chromosome 1 to X.