Survival curves. These line graphs show the percentage of survival for WT, HbA, and SCD mice from (A) day 1 of OVA implantation to day 15 prior to exposure to aerosolized OVA and from (B) day 15 to day 23 for UnSen, LoSen, and HiSen WT, HbA, and SCD mice. Total numbers of mice were as follows: On day 1, WT mice (n = 28) were placed in the UnSen protocol or were subjected to OVA implantation (n = 38). On day 15, all of the OVA-implanted WT mice that survived (100%) were divided into the LoSen protocol (n = 14) and the HiSen protocol (n = 24). On day 1, HbA mice (n = 25) were placed in the UnSen protocol or were subjected to OVA implantation (n = 60). On day 15, all of the OVA-implanted HbA mice that survived (n = 60) were divided into the LoSen protocol (n = 29) and the HiSen protocol (n = 31). On day 1, SCD mice (n = 21) were placed in the UnSen protocol or were subjected to OVA implantation (n = 54). On day 15, the surviving OVA-implanted SCD mice (n = 48) were divided into the LoSen protocol (n = 21) and the HiSen protocol (n = 27). Circles and triangles represent mice that died (when less than 100%) and lived (when = 100%) after OVA sensitization (days 1-14) or after OVA aerosolization (days 15-23). ** indicates significant increase in mortality (P < .01).