IRF-4 suppresses B-lymphoid leukemogenesis by BCR/ABL in mice. (A) Survival of mice receiving transplantation of bone marrow cells infected with BCR/ABL-GFP⁺Neo-, BCR/ABL-GFP⁺IRF-4-, BCR/ABL-GFP⁺IRF-8-, or GFP-containing retroviruses. Survival curves were generated by Kaplan-Meier survival analysis. One BCR/ABL-GFP⁺IRF-4 BMT mouse succumbed to disease and died, whereas 13 of 14 mice remain alive in more than 1 year of observation. (B) Immunophenotype of pleural effusion from moribund BCR/ABL-GFP⁺Neo (top panel) and BCR/ABL-GFP⁺IRF-8 (bottom panel) BMT mice.