Production of DCs from lymphoid progenitors in HSV-1–infected mice. (A) Total numbers of pro-B/large pre-B, small pre-B, B, pDCs, IKDCs, and cDCs were enumerated from femurs of mice after 7 days of acute infection or 30 days of latent HSV-1 infection. Percentage control values represent BM cellularity in each condition relative to BM cellularity in uninfected controls. The results are representative of 3 independent experiments. CLPs were double sorted from HSV-1–infected and control mice and placed in lymphoid cultures for 8 days. (B) The indicated flow cytometry gates were used to discriminate B220⁺CD19⁻CD11c⁺CD11b⁻ pDC/NK-like IKDCs and B220⁻CD19⁻CD11c⁺CD11b⁺ cDCs. (C,D) Total numbers of recovered cells of each type after acute and latent infection were calculated and expressed as yields per input of common lymphoid progenitor (*significant difference, P < .05 by t test). Data are representative of 3 independent experiments. Error bars represent SEM.