All combinations of inhibitory MHC class I receptors are represented in human NK-cell repertoires. In the upper part of the figure, the gray bars give the frequencies for CD56dim NK cells having the receptor combination denoted by the black, filled boxes below each bar; shown are data for a representative donor (rd). The lower part of the figure gives mean (m) and range (r) frequencies for NK subsets expressing different numbers of inhibitory MHC class I receptors, both for the representative donor alone and all 27 donors analyzed. The donors are grouped by KIR haplotype combination. A and B refer to KIR haplotypes defined at the low resolution of gene content16 ; A1 is defined at the high resolution of allele content. The representative donor has the A1A1 genotype. See Figure S1 for donor KIR and HLA class I genotypes.