Identification of IL-10, IL-6, and STAT3 target genes in ABC DLBCL cells. (A) Gene-expression patterns of lymphoma cell line OCI-Ly10 treated with IL-6 for 0.5, 1, 3, 6, and 24 hours. Genes indicated with an asterisks are also IL-10 targets. (B) Gene-expression patterns of lymphoma cell line OCI-Ly3 treated with IL-10 for 1, 3, 6, 24, 48, and 96 hours. Genes marked with an asterisk are also IL-6 targets. (C) Comparison of the genes in response to IL-6 or IL-10 treatment. (D) Western blotting showing down-regulation of total STAT3 and phospho-STAT3 protein expression in OCI-Ly10 cell transfected with STAT3 siRNA. (E) Gene-expression patterns of lymphoma cell line OCI-Ly10 transient transfected with STAT3 siRNA pool for 8, 24, and 48 hours.