Serial magnetic resonance (MR) images of cerebral infarcts after tMCAO in WT and VWF^−/− mice. Serial coronal T2-weighted gradient echo MR sequences show hyperintense (bright) ischemic lesions (white dashed lines) at day 1 after tMCAO in WT mice (top) and VWF^−/− mice (middle). Infarcts at day 1 are smaller in VWF^−/− mice than in WT mice and remain restricted to the basal ganglia at day 7 (bottom) excluding delayed infarct growth. Hypointense (dark) areas indicative of intracerebral hemorrhage were always absent during the infarct course in both VWF^−/− mice (middle and bottom) and WT controls (top; n = 8 per group).