Thrombus formation is diminished in ILK-deficient blood. Whole blood from KO and control (Ctrl) mice was labeled with DiOC₆ and perfused through a collagen-coated capillary at a shear rate of 1000 s⁻¹. Representative topological and composite (stacked) views of the thrombi formed (A) show more large thrombi are formed in the control (Ctrl) compared with the KO, though the KO sample still shows formation of many small plaques. (B) The average maximum depth of thrombi formed in a field of view (mean ± SEM, n = 10; *P ≤ .05). The number of thrombi formed (C) was not significantly altered in the control and KO samples (mean ± SEM, n = 10; P = .34).