PPAR-γ ligands decrease fMLP-induced adhesion of PMNs to fibrinogen. Human PMNs were isolated and seeded onto fibrinogen-coated plates. After 20 minutes, PMNs were treated with troglitazone (5 or 10 μM) or 15d-PGJ₂ (5 or 10 μM) or vehicle for 2 hours followed by treatment with 10⁻⁷ fMLP for 45 minutes. Adherent cells were trypsinized and counted using a Coulter counter. *P < .05 compared with DMSO-treated cells. Results are expressed as the average of 3 independent experiments performed in quadruplicate. Tro indicates troglitazone; PGJ₂, 15-deoxy-Δ^12,14-prostaglandin J₂; Ctrl, without fMLP treatment. Error bars represent SEM.