sICAM-5 and sICAM-1 differentially regulate the cytokine expression in T cells. sICAM-1 potentiated the anti-CD3–induced activation on IL-4 (A), IFN-γ (B), TNF (C), and TGF-β1 (D) mRNAs, whereas sICAM-5 had no effect on IL-4 (A) and TNF (C) mRNAs but significantly promoted the anti-CD3–induced activation on IFN-γ (B) and TGF-β1 (D) mRNAs. Data are dot plots with mean values shown (n = triplicates from 3 donors; ***P < .001).