Correlation of chromosomal abnormalities with survival in AML based on an MRC study.³⁸  (A) Correlation with translocations which is the subset with the best response to treatment. Note that of all translocations, those involving 11q23 have the poorest survival. This study, published in 1998, does not reflect the enormous improvement in survival in APL associated with treatment with ATRA and arsenic trioxide. The yellow line for those thought to have a normal karyotype is the same in this and panel B. (B) Correlation with abnormalities that have the poorest outcome. As noted in Figure 3, these abnormalities tend to be more common in older patients.