The disease progression in the MMTV-Cre;Mib1^f/f mice. (A) Biweekly monitoring of the peripheral blood cells from MMTV-Cre;Mib1^+/f (dotted line, representative data) and MMTV-Cre;Mib1^f/f (solid line, 9 individuals) mice by flow cytometry. (B,C) The representative CD11b/Gr-1 (B) and B220/CD11b (C) expression profiles of the blood cells of MMTV-Cre;Mib1^+/f (WT) and MMTV-Cre;Mib1^f/f (MT) mice are shown. (B′) Flow cytometric analysis of the CD11b⁺Gr-1^lo/− gated blood cells from WT (i) and MT (ii) at 20 and 15 weeks of age, respectively. Note that the CD11b⁺Gr-1^lo/− cells consisted of a significant proportion of CCR-3⁺ and SSC^hi cells in the blood cells of MT.