SK-1 regulates EC permeability and vascular leakage in vivo. (A) The absorbances of the dye eluted from the injected areas (PBS, VEGF, and histamine) of 10 age- and sex-matched WT mice and 10 SK-1 KO mice (SK-1^−/−) were read at 620 nm. The pooled results (mean ± SEM) for each group of mice are shown (*P < .05 vs WT mice injected with PBS). (B) The absorbances of the dye eluted from the injected areas of 8 age- and sex-matched WT mice and 8 SK-1 transgenic mice (SK-1^+/+) were read at 620 nm. The pooled results (mean ± SEM) for each group of mice are shown (*P < .05 vs the WT mice injected with PBS).