American Society of Hematology

Figure 6

$Figure 6. HSCs in aged FoxO3a-deficient mice are phenotypically similar to HSCs in FoxO3a-deficient mice injected with 5-FU. (A,B) Data are mean frequencies (%) plus or minus SD of phospho-AKT (A)– or ERK (B)–positive cells in LSK cells from aged FoxO3a+/+ (□; n = 3) or FoxO3a−/− (■; n = 3) cells. *P < .05. (C) Spred2 and p27Kip1 are down-regulated in LSK cells from aged FoxO3a-deficient mice. Data are means plus or minus SD of Spred2 and p27Kip1 expression relative to GAPDH in LSK or unfractionated cells from aged FoxO3a-deficient mice (■; n = 3) relative to unfractionated cells from aged wild-type mice (□; n = 3). *P < .01.$

HSCs in aged FoxO3a-deficient mice are phenotypically similar to HSCs in FoxO3a-deficient mice injected with 5-FU. (A,B) Data are mean frequencies (%) plus or minus SD of phospho-AKT (A)– or ERK (B)–positive cells in LSK cells from aged FoxO3a^+/+ (□; n = 3) or FoxO3a^−/− (■; n = 3) cells. *P < .05. (C) Spred2 and p27Kip1 are down-regulated in LSK cells from aged FoxO3a-deficient mice. Data are means plus or minus SD of Spred2 and p27Kip1 expression relative to GAPDH in LSK or unfractionated cells from aged FoxO3a-deficient mice (■; n = 3) relative to unfractionated cells from aged wild-type mice (□; n = 3). *P < .01.

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