RI-BPI selectively kills BCR-type DLBCL cells. Dose-response curves for RI-BPI in a panel of 11 DLBCL cell lines. The x-axis shows the dose of BPI in micromoles. The y-axis shows the effect of RI-BPI compared with CP on cell viability. ● indicates BCL6-dependent cell lines (BCR-type); and , BCL6-independent (OxPhos-type) cell lines. The goodness-of-fit for the experimental data to the median-effect equation is represented by the linear correlation coefficient (r) obtained from the logarithmic form of this equation. There was a statistically significant difference between the average of the GI₅₀ values of BCL6-dependent versus BCL6-independent cell lines (P < .001, t test).