American Society of Hematology

Figure 1

$Figure 1. Deregulation of miRNA involved in hematopoiesis and innate immunity in HTLV-I–infected cells. (A) miRNA involved in the different steps of hematopoiesis and showing deregulated expression in HTLV-I–transformed cells in vitro and ATL tumor cells ex vivo. MPP indicates myeloid pluripotent progenitors, HSC, hematopoietic stem cells; CMP, common myeloid progenitors; CLP, common lymphocyte progenitors; and CFU-GM, colony-forming units granulocyte-macrophage. (B) Table representation of mature miRNA deregulated in HTLV-I–infected cells in vitro and ex vivo identified by mirVana miRNA Bioarrays platform and real-time RT-PCR. The miRNA enriched fraction was obtained by passing total RNA through a flashPAGE Fractionator apparatus (Ambion, Austin, TX). The 3′ ends of the RNA molecules were tailed and labeled using the mirVana miRNA Labeling Kit (Ambion) and analyzed as described in “Methods.” nd indicates not determined.$

Deregulation of miRNA involved in hematopoiesis and innate immunity in HTLV-I–infected cells. (A) miRNA involved in the different steps of hematopoiesis and showing deregulated expression in HTLV-I–transformed cells in vitro and ATL tumor cells ex vivo. MPP indicates myeloid pluripotent progenitors, HSC, hematopoietic stem cells; CMP, common myeloid progenitors; CLP, common lymphocyte progenitors; and CFU-GM, colony-forming units granulocyte-macrophage. (B) Table representation of mature miRNA deregulated in HTLV-I–infected cells in vitro and ex vivo identified by mirVana miRNA Bioarrays platform and real-time RT-PCR. The miRNA enriched fraction was obtained by passing total RNA through a flashPAGE Fractionator apparatus (Ambion, Austin, TX). The 3′ ends of the RNA molecules were tailed and labeled using the mirVana miRNA Labeling Kit (Ambion) and analyzed as described in “Methods.” nd indicates not determined.

This Feature Is Available To Subscribers Only