Figure 5
![Figure 5. CD38 signaling requires Lyn, Fyn, PI3K, and Erk to induce proliferation of T2 B lymphocytes. (A) T2 B cells from Lyn−/−, Fyn−/−, or wild-type mice were stimulated 48 hours as indicated. (B) T2 B cells from wild-type mice were preincubated 30 minutes with DMSO, LY294002 (LY), or PD98059 (PD). Cells with the drug were stimulated as indicated above. Each well was pulsed with 1 μCi [3H] thymidine 8 hours before being harvested. Results are expressed as mean plus or minus SD from 3 independent experiments (P < .05 or P < .01 as indicated, Student t test).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/111/7/10.1182_blood-2007-08-107714/5/zh80070817550005.jpeg?Expires=1735514661&Signature=tXda0202d7t3ulH446W-4zHDAu5z5frFQmUYPv46frNpcYB5j3oKy5PwFA2S5nT0RQA8Dpnne66waTtpLdEpcOKJaKTsN63lYJiIuIEaHWMe2tlq2a41lssuqa4v4plbqdVKaa89ZMv7AVjbnH8EahazCcZzXqSYlqWhvOTqQ0Yeu~79KP4OFf3wqcyhnj2XmjB4cABjTzjw9cdI3Um77hKsHtw9jGrER10C~hXtyD0GwecYWi0akWjLEZsPzK20LksmsL83EWxDWgoEiNLHL8uUeUpCq1N4sXJRGOuP5pHinHmjBUsmKYXYme~bh5QvPsf1g8I69OjO~rEPVxUBIg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
CD38 signaling requires Lyn, Fyn, PI3K, and Erk to induce proliferation of T2 B lymphocytes. (A) T2 B cells from Lyn−/−, Fyn−/−, or wild-type mice were stimulated 48 hours as indicated. (B) T2 B cells from wild-type mice were preincubated 30 minutes with DMSO, LY294002 (LY), or PD98059 (PD). Cells with the drug were stimulated as indicated above. Each well was pulsed with 1 μCi [3H] thymidine 8 hours before being harvested. Results are expressed as mean plus or minus SD from 3 independent experiments (P < .05 or P < .01 as indicated, Student t test).
