Figure 2
![Figure 2. Erythropoietin but not hypoxia inhibits hepcidin induction through the inflammatory pathway. (A) Hepcidin mRNA levels in the liver of mice treated with saline (control [CTL]), EPO, LPS, and mice with combined treatments (EPO + LPS). (B) Hepcidin mRNA levels in the liver of mice treated with saline (CTL), mice subjected to 10% oxygen (hypoxia [Hpx]), LPS, and mice with combined treatments (Hpx + LPS). Hepatic hepcidin expression was quantified by real-time RT-PCR and normalized to β-actin. The hepcidin/β-actin ratios are shown, each symbol representing 1 mouse. Statistical analysis was performed by 1-way ANOVA; **P < .001 for comparison with control mice. n.s. indicates not significant.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/113/15/10.1182_blood-2008-08-173641/7/zh80180934400002.jpeg?Expires=1735501790&Signature=FQqpqf1lyfC8bg9oprOTjxqFcma9z00SFHNWi0CNV8n3PAZyOKYoIB7p0fwlsbSY8iOXObuwjaxF5lQE1bQjD8U~ctR4xQoJd52TubWhsRZfGrHYrkJlrTcJpOWXADIsIxdPZErjAPjVI5Wxrfcl676Tk0nYqHQ6c70tH6OoT7L0dsSsrb9ZqVHDx8udBXNsVBS5It-1vI-AYX8keDX-1K~y-9Rm5Kjsl487LbBozxpXt3u3ctrBHIVOYxTO24TC4jbPLwPwD5YlNu1Q6RlwX0mOaiS15ux-Y-vR8aUs2TNBPDI9M6lfaaRBi69hdl7BLAX-yExJX7YdMj4hVcIu2A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Erythropoietin but not hypoxia inhibits hepcidin induction through the inflammatory pathway. (A) Hepcidin mRNA levels in the liver of mice treated with saline (control [CTL]), EPO, LPS, and mice with combined treatments (EPO + LPS). (B) Hepcidin mRNA levels in the liver of mice treated with saline (CTL), mice subjected to 10% oxygen (hypoxia [Hpx]), LPS, and mice with combined treatments (Hpx + LPS). Hepatic hepcidin expression was quantified by real-time RT-PCR and normalized to β-actin. The hepcidin/β-actin ratios are shown, each symbol representing 1 mouse. Statistical analysis was performed by 1-way ANOVA; **P < .001 for comparison with control mice. n.s. indicates not significant.
