Mice cured with CpG + anti-OX40 + anti-CTLA4 combination are protected from rechallenge. Naive mice (●) or mice cured from A20 tumors with CpG + anti-OX40 + anti-CTLA4 given 100 days earlier (■) were (re)challenged with 2.5 × 106 A20 tumors cells dorsally. Growth curves represent the average size of the tumor (n = 10 mice per group).