Cumulative survival according to platelet count and bleeding score. Bleeding-free survival curves calculated according to platelet count assessed at baseline (A) and to bleeding severity score (B) of the 67 patients with VWD2B. In panel A, 2 groups of patients are represented according to absence (≥ 140 × 10³/μL;dashed line) or presence (< 140 × 10³/μL; solid line) of thrombocytopenia. In panel B, 3 groups of patients are represented according to tertiles of bleeding severity score, ie, < 4 (small dashed line), 4-8 (big dashed line), more than 8 (solid line). In all curves, each step represents a bleeding event.