Figure 6
Nucleofection of AONs results in correction of IL-12 response. A total of 106 activated T cells per well from an IL-12Rβ1−/− patient and a control were nucleofected without AONs, with AON02 plus AON03, or with AON02 plus AON128, and subsequently stimulated for 6 days with 75 ng/mL IL-18 or 5000 ng/mL IL-12 or 5000 ng/mL IL-12 and 75 ng/mL IL-18. IFN-γ production was analyzed by ELISA. The bars represent averages of an experiment performed in duplicate.
