Chromosome distribution of genes and SNPs associated with MTXPG. (A) Genes whose expression is significantly associated (P < .05) with MTXPG in 145 patients are overrepresented on chromosome 18 (P = 1.3 × 10−6, χ2 test) and chromosome 10 (P = 1.1 × 10−7, χ2 test). (B) Single SNP CNV in 82 patients significantly associated (P < .01) with MTXPG is overrepresented on chromosome 18 (P < 1.0 × 10−7, χ2 test) and on chromosome 10 (P < 1.0 × 10−7, χ2 test).