Hematopoietic abnormalities are seen in the Ts1Cje bone marrow. (A) The number of LSK cells in the Ts1Cje BM is reduced (n = 3 mice of each genotype). (B) Ts1Cje BM has a reduced cellularity compared with disomic controls (n = 3 mice of each genotype). (C) Ts1Cje BM HSCs are able to reconstitute hematopoiesis as efficiently as disomic competitor cells. BM from 3 mice of each genotype was transplanted into 5 recipients per donor mouse. (D) Myeloid progenitor cells in the Ts1Cje BM show a reduced proportion of CMPs and a concomitant increase in GMPs. MEPs are not affected (n = 3 mice of each genotype). *P < .05; **P < .01. Error bars represent SEM.