Prosurvival Bcl-2 proteins inhibit HDACi-induced apoptosis. 4242 Eμ-myc/MSCV, Eμ-myc/Bcl-2, Eμ-myc/Bcl-XL, Eμ-myc/Bcl-w, Eμ-myc/Mcl-1, and Eμ-myc/A1 lymphomas were treated for 24 hours with increasing concentrations of (A) vorinostat or (B) VPA. Cell membrane disruption (left panels) and MOMP (right panels) were assessed by PI and TMRE staining, respectively. Results shown are the mean and SE from at least 3 separate experiments.