Hypersensitivity of PSF1^+/− mice to 5-FU. (A) Survival curves after 5-FU injection. ○ indicate PSF1^+/− 8-week-old mice (n = 10); and ●, wild-type 8-week-old mice (n = 10). (B) Number of mononuclear cells in the peripheral blood of wild-type (●) and PSF1^+/− (○) mice over time after 5-FU injection. 5-FU was injected into 8-week-old mice on day 0. Means plus or minus SEM are shown (n = 10). *P < .05 vs those in PSF1^+/− mice on days 2, 4, 6, 8, and 10 after BM ablation with 5-FU. (C) Kinetics of BM cells after 5-FU injection. +/+ indicates wild-type mice; and +/−, PSF1^+/− mice. Results of FACS analysis are shown. SSC indicates side-scattered light; and FSC, forward-scattered light. Blue represents RBC; and red, leukocytes.