Figure 4
Figure 4. Transcription factor coexpression in hematopoietic lineages. Shown at the top is the hematopoietic differentiation hierarchy with key hematopoietic transcription factors GATA1, GATA2, Meis1, SPI1, GATA3, and EBF1. Only MEIS1 and EBF1 were expressed in a single lineage, whereas all other factors were expressed in 2 or more lineages. Tabulated underneath each factor are those transcription factors that share their respective expression pattern, suggesting either direct regulation or common upstream regulators. Expression of GATA1 in CD66b+ cells was an order of magnitude lower than in erythroblasts and megakaryocytes.

Transcription factor coexpression in hematopoietic lineages. Shown at the top is the hematopoietic differentiation hierarchy with key hematopoietic transcription factors GATA1, GATA2, Meis1, SPI1, GATA3, and EBF1. Only MEIS1 and EBF1 were expressed in a single lineage, whereas all other factors were expressed in 2 or more lineages. Tabulated underneath each factor are those transcription factors that share their respective expression pattern, suggesting either direct regulation or common upstream regulators. Expression of GATA1 in CD66b+ cells was an order of magnitude lower than in erythroblasts and megakaryocytes.

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