Histology from a patient with nodular sclerosis Hodgkin lymphoma involving the cerebellum. A Reed-Sternberg cell () is seen in the center of the panel (40×, hematoxylin-eosin stain) (A). The large cells stained for CD30 (B). The cells are focally CD15 positive (C) and CD45 negative (D). All images were acquired at 40× magnification using an Olympus CX411 microscope and an Olympus DP70 camera with medium acquisition software (Melville, NY).