Platelet granule secretion requires SNARE proteins. Platelets contain α-granules, dense (δ-) granules, and a few lysosomes. Platelet activation results in cytoskeletal rearrangements, centralization of granules, and fusion of granules with the target membrane (plasma membrane or the open canalicular system). Secretion involves the assembly of granule v-SNAREs (eg, VAMP-8) and target membrane t-SNAREs (eg, syntaxin 2, SNAP-23) into a complex allowing membrane fusion and exocytosis.