Figure 2
Figure 2. XN down-regulates the TNF-induced gene products linked to proliferation, apoptosis, and invasion of chronic myeloid leukemia cells. (A) XN suppresses the TNF-induced expression of proliferative proteins. KBM-5 cells were incubated with 50 μM XN for 4 hours and then treated with 1 nM TNF for the indicated times. Whole-cell extracts were prepared and analyzed by Western blotting with the indicated antibodies. (B) XN inhibits the expression of TNF-induced antiapoptotic proteins. KBM-5 cells were incubated with 50 μM XN for 4 hours and then treated with 1 nM TNF for the indicated times. Whole-cell extracts were prepared and analyzed by Western blotting with relevant antibodies. (C) XN inhibits the expression of TNF-induced metastatic proteins. KBM-5 cells were incubated with 50 μM XN for 4 hours and then treated with 1 nM TNF for the indicated times. Whole-cell extracts were prepared and analyzed by Western blotting with relevant antibodies.

XN down-regulates the TNF-induced gene products linked to proliferation, apoptosis, and invasion of chronic myeloid leukemia cells. (A) XN suppresses the TNF-induced expression of proliferative proteins. KBM-5 cells were incubated with 50 μM XN for 4 hours and then treated with 1 nM TNF for the indicated times. Whole-cell extracts were prepared and analyzed by Western blotting with the indicated antibodies. (B) XN inhibits the expression of TNF-induced antiapoptotic proteins. KBM-5 cells were incubated with 50 μM XN for 4 hours and then treated with 1 nM TNF for the indicated times. Whole-cell extracts were prepared and analyzed by Western blotting with relevant antibodies. (C) XN inhibits the expression of TNF-induced metastatic proteins. KBM-5 cells were incubated with 50 μM XN for 4 hours and then treated with 1 nM TNF for the indicated times. Whole-cell extracts were prepared and analyzed by Western blotting with relevant antibodies.

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