PC model analysis. (A) Flow diagram for the calculation of the MDS risk score. Kaplan-Meier curves grouped by PC model scores. (B) Overall survival after diagnosis of MDS, calculated by the resubstitution classifiers. (C) Overall survival after diagnosis of MDS, calculated by the hierarchical LOO classifiers. (D) Time to AML transformation after diagnosis of MDS, calculated by the resubstitution classifiers. (E) Time to AML transformation after diagnosis of MDS, calculated by the hierarchical LOO classifiers.